[HTML][HTML] Enriching human interactome with functional mutations to detect high-impact network modules underlying complex diseases
Rapid progress in high-throughput-omics technologies moves us one step closer to the
datacalypse in life sciences. In spite of the already generated volumes of data, our …
datacalypse in life sciences. In spite of the already generated volumes of data, our …
[HTML][HTML] Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations
D Xiong, Y Qiu, J Zhao, Y Zhou, D Lee, S Gupta… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Human genome sequencing studies have identified numerous loci associated with complex
diseases. However, translating human genetic and genomic findings to disease …
diseases. However, translating human genetic and genomic findings to disease …
[HTML][HTML] Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery
In this study, we integrate the outcomes of co-expression network analysis with the human
interactome network to predict novel putative disease genes and modules. We first apply the …
interactome network to predict novel putative disease genes and modules. We first apply the …
dmGWAS: dense module searching for genome-wide association studies in protein–protein interaction networks
Motivation: An important question that has emerged from the recent success of genome-
wide association studies (GWAS) is how to detect genetic signals beyond single …
wide association studies (GWAS) is how to detect genetic signals beyond single …
Uncovering disease-disease relationships through the incomplete interactome
INTRODUCTION A disease is rarely a straightforward consequence of an abnormality in a
single gene, but rather reflects the interplay of multiple molecular processes. The …
single gene, but rather reflects the interplay of multiple molecular processes. The …
Differential network analysis of human tissue interactomes highlights tissue-selective processes and genetic disorder genes
O Basha, CM Argov, R Artzy, Y Zoabi, I Hekselman… - bioRxiv, 2019 - biorxiv.org
Motivation Differential network analysis, designed to highlight interaction changes between
conditions, is an important paradigm in network biology. However, network analysis …
conditions, is an important paradigm in network biology. However, network analysis …
[HTML][HTML] Pathway analyses and understanding disease associations
Y Liu, MR Chance - Current genetic medicine reports, 2013 - Springer
High throughput technologies have been applied to investigate the underlying mechanisms
of complex diseases, identify disease associations, and help to improve treatment. However …
of complex diseases, identify disease associations, and help to improve treatment. However …
[HTML][HTML] Community of protein complexes impacts disease association
One important challenge in the post-genomic era is uncovering the relationships among
distinct pathophenotypes by using molecular signatures. Given the complex functional …
distinct pathophenotypes by using molecular signatures. Given the complex functional …
Open community challenge reveals molecular network modules with key roles in diseases
Identification of modules in molecular networks is at the core of many current analysis
methods in biomedical research. However, how well different approaches identify disease …
methods in biomedical research. However, how well different approaches identify disease …
Differential network analysis of multiple human tissue interactomes highlights tissue-selective processes and genetic disorder genes
Motivation Differential network analysis, designed to highlight network changes between
conditions, is an important paradigm in network biology. However, differential network …
conditions, is an important paradigm in network biology. However, differential network …