Decreased daytime illumination leads to anxiety-like behaviors and HPA axis dysregulation in the diurnal grass rat (Arvicanthis niloticus)

T Ikeno, SP Deats, J Soler, JS Lonstein, L Yan - Behavioural brain research, 2016 - Elsevier
The impact of ambient light on mood and anxiety is best exemplified in seasonal affective
disorder, in which patients experience depression and anxiety in winter when there is less …

Depression-Like Responses Induced by Daytime Light Deficiency in the Diurnal Grass Rat (Arvicanthis niloticus)

G Leach, W Adidharma, L Yan - PLoS One, 2013 - journals.plos.org
Seasonal Affective Disorder (SAD) is one of the most common mood disorders with
depressive symptoms recurring in winter when there is less sunlight. The fact that light is the …

Hypothalamic dopaminergic neurons in an animal model of seasonal affective disorder

SP Deats, W Adidharma, L Yan - Neuroscience letters, 2015 - Elsevier
Light has profound effects on mood regulation as exemplified in seasonal affective disorder
(SAD) and the therapeutic benefits of light therapy. However, the underlying neural …

Effects of bright light therapy on neuroinflammatory and neuroplasticity markers in a diurnal rodent model of Seasonal Affective Disorder

A Costello, K Linning-Duffy, C Vandenbrook… - Annals of …, 2023 - Taylor & Francis
Background Bright light therapy (BLT) is widely used for treating Seasonal Affective Disorder
(SAD). However, the neural mechanisms underlying the therapeutic effects of BLT remain …

Daytime light deficiency leads to sex-and brain region-specific neuroinflammatory responses in a diurnal rodent

A Costello, K Linning-Duffy, C Vandenbrook… - Cellular and molecular …, 2023 - Springer
Seasonal changes in peripheral inflammation are well documented in both humans and
animal models, but seasonal changes in neuroinflammation, especially the impact of …

Orexinergic signaling mediates light-induced neuronal activation in the dorsal raphe nucleus

W Adidharma, G Leach, L Yan - Neuroscience, 2012 - Elsevier
Seasonal affective disorder (SAD), a major depressive disorder recurring in the fall and
winter, is caused by the reduction of light in the environment, and its depressive symptoms …

Light as a modulator of emotion and cognition: Lessons learned from studying a diurnal rodent

L Yan, JS Lonstein, AA Nunez - Hormones and Behavior, 2019 - Elsevier
Light profoundly affects the behavior and physiology of almost all animals, including
humans. One such effect in humans is that the level of illumination during the day positively …

Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod

J Itzhacki, D Clesse, Y Goumon… - Brain Structure and …, 2018 - Springer
Seasonal affective disorder (SAD), beyond mood changes, is characterized by alterations in
daily rhythms of behavior and physiology. The pathophysiological conditions of SAD involve …

[HTML][HTML] Blue light at night produces stress-evoked heightened aggression by enhancing brain-derived neurotrophic factor in the basolateral amygdala

Z Li, CS Lee, S Chen, B He, X Chen, HY Peng… - Neurobiology of …, 2024 - Elsevier
Light is an underappreciated mood manipulator. People are often exposed to electronic
equipment, which results in nocturnal blue light exposure in modern society. Light pollution …

Blue light deprivation produces depression-like responses in Mongolian Gerbils

H Hu, C Kang, X Hou, Q Zhang, Q Meng, J Jiang… - Frontiers in …, 2020 - frontiersin.org
Background Depression is a leading cause of disability worldwide and is a major contributor
to the overall global burden of disease, but its etiology is poorly understood. It has been …