Abstract Purpose: Interleukin (IL)-8 is an important mediator of angiogenesis, tumorigenicity,
and metastasis in transitional cell carcinoma (TCC) of the bladder. Nuclear factor κB (NF …

We investigated the role of NF-κB in the development and progression of urothelial cancer
as well as cross-talk between NF-κB and androgen receptor (AR) signals in urothelial cells …

Inflammatory cytokines may be a critical component of epithelial cancer progression. We
examined the role of interleukin (IL)-5 in the migration of bladder cancer cells. The …

Purpose: To characterize the basal and activated form of nuclear factor-κB (NF-κB) complex
in normal urothelial cell cultures after stimulation with tumor necrosis factor-alpha (TNF-α) …

Our previous report of predominant activation of nuclear transcription factor NF-κB in the
bladder urothelium of interstitial cystitis (IC) patients suggests a potential role for this nuclear …

Purpose: The expression of interleukin-6 (IL-6) by normal and malignant urothelium in
response to bacillus Calmette-Guerin (BCG) may have direct and indirect effects on the …

Purpose Toll-like receptor 4 (TLR4) was found to be aberrantly expressed in bladder cancer,
inducing some genes expression and facilitating tumor progression. Recent data suggest …

Identification of potential tumor markers will help stratify and identify a tumor's malignant
potential and its response to specific therapies. IL-6 has been reported to be a predictor in …

Signaling and regulation of transcription factor nuclear factor-kappaB (NF-κB) has been an
area of extensive research since its first discovery nearly three decades ago. Members of the …

Abstract The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation
and angiogenesis with malignancy. Since nuclear factor-κB (NF-κB) is a potential sign for …