Objective While the molecular events controlling insulin secretion from β-cells have been
documented in detail, the exact mechanisms governing glucagon release by α-cells are …

The major role of glucagon is to promote hepatic gluconeogenesis and glycogenolysis to
raise blood glucose levels during hypoglycemic conditions. Several animal models have …

An important feature of glucose homeostasis is the effective release of glucagon from the
pancreatic α cell. The molecular mechanisms regulating glucagon secretion are still poorly …

Glucagon and insulin are the main regulators of blood glucose. While the actions of insulin
are extensively mapped, less is known about glucagon. Besides glucagon's role in glucose …

Glucagon is usually viewed as an important counterregulatory hormone in glucose
metabolism, with actions opposing those of insulin. Evidence exists that shows glucagon is …

Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate
measurement of glucagon has been essential for uncovering its pathological hypersecretion …

Objectives Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects
with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a …

Aims/hypothesis Pancreatic islet cells and clonal beta-cell lines can metabolise L-glutamine
at high rates. The pathway of L-glutamine metabolism has traditionally been described as L …

Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin
from pancreatic islets. When glucose is low, glucagon is released from α-cells to stimulate …

Glucagon is a critical regulator of glucose homeostasis; however, mechanisms regulating
glucagon action and α-cell function and number are incompletely understood. To elucidate …