Gluconeogenesis, a pathway for glucose synthesis from non-carbohydrate substances,
begins with the synthesis of oxaloacetate (OA) from pyruvate and intermediates of citric acid …

Maintenance of glucose homeostasis is essential for normal physiology. Deviation from
normal glucose levels, in either direction, increases susceptibility to serious medical …

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs
and maintain an individual's health. The liver has a major role in the control of glucose …

Glucagon is secreted from islet α cells and controls blood levels of glucose in the fasting
state. Impaired glucagon secretion predisposes some patients with type 1 diabetes mellitus …

Aims/hypothesis Intra-islet and gut–islet crosstalk are critical in orchestrating basal and
postprandial metabolism. The aim of this study was to identify regulatory proteins and …

Glucagon action is transduced by a G protein-coupled receptor located in liver, kidney,
intestinal smooth muscle, brain, adipose tissue, heart, pancreatic β-cells, and placenta …

Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion
defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive …

Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2
diabetes, and there is consequently extensive interest in increasing endogenous GLP-1 …

Glucagon and insulin are commonly believed to have counteracting effects on blood
glucose levels. However, recent studies have demonstrated that glucagon has a physiologic …

Mammary epithelial cells transition between periods of proliferation and quiescence during
development, menstrual cycles, and pregnancy, and as a result of oncogenic transformation …