BACKGROUND: Cytochrome P450 3A4 (CYP3A4) is the major cytochrome involved in
metabolizing of> 60% of all drugs used in humans. A number of allelic variations in CYP3A4 …

Objective Cytochrome P4503A (CYP3A) activity exhibits considerable interindividual
variability. Possible differences in CYP3A activity were investigated in European American …

Wild type genotypes (CYP2D6) and their allelic variants have been described in a sample of
a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6* 3 and …

Objective: To determine and compare the cytochrome P450 (CYP) 2C9, CYP2C19 and
CYP2D6 allele and genotype frequencies in the Ashkenazi Jewish (AJ) population with …

Abstract CYP2D6 genotyping (CYP2D6* 3, CYP2D6* 4, CYP2D6* 5, CYP2D6* 13,
CYP2D6* 16 alleles and gene duplications) was previously performed on 1053 Caucasian …

The aim of the present study was to determine the prevalence of the most common allelic
variants of the polymorphic cytochrome P450 (CYP) enzymes CYP2D6, CYP2C9, CYP2C19 …

Background: CYP2C19 is an enzyme for drug metabolism, and its genetic polymorphisms
produce interpersonal variations in drug responses. The two major loss-of-function alleles …

Aim The aim of this study was to obtain pharmacogenetic data in a Vietnamese population
on genes coding for proteins involved in the elimination of drugs currently used for the …

Objective The purpose of the study was to study the distribution of poor and extensive
metabolizers of CYP2C19 and CYP2D6 and to genotype for CYP2C8 and CYP2C9 among …

The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important
role in the activation and inactivation of xenobiotics. These enzymes have been associated …