Objectives To investigate the CYP1A2 genotype-phenotype relationship and to compare
CYP1A2 genetic polymorphisms and enzyme activity in terms of the effect of smoking and …

Background The cytochrome P450 isoenzymes CYP2C19 and CYP2D6 catalyze reactions
involved in the metabolism of many widely used drugs. Their polymorphisms give rise to …

Background The MDR1 gene presents several genetic polymorphisms with pharmacological
implications. Therefore, the aim of the present study is to establish the genotype and allele …

Abstract Objectives To phenotype 200 healthy North Indians for cytochrome P450 3A
(CYP3A) activity by measuring urinary ratio of 6β-OH-cortisol/cortisol (6β-OH-CS/CS) and to …

Aims To investigate the distribution characteristics of CYP1A2 in a Chinese population, and
to examine gender‐related differences in CYP1A2 activity. Methods Two hundred and …

The objectives of the this study were to assess the influence of CYP3A5 genotype and sex
on the variability in total CYP3A activity and to compare 4β-hydroxycholesterol and …

Objectives Cytochrome P450 enzymes play a dominant role in drug elimination and
variation in these genes is a major source of interindividual differences in drug response …

Background Omeprazole is metabolized by the hepatic cytochrome P450 (CYP) 2C19
enzyme to 5-hydroxyomeprazole. CYP2C19 exhibits genetic polymorphisms responsible for …

Heading Abstract Objective. The goal of this study was to determine the frequencies of allelic
variants of CYP2B6 and CYP3A5 in the Japanese population. Methods. Genotyping of …

Objectives: It is known that the interindividual and interethnic variability of the genetic
polymorphisms of CYP2D6 plays an important role in the presentation of adverse drug …