HDL cholesterol: reappraisal of its clinical relevance

W März, ME Kleber, H Scharnagl, T Speer… - Clinical Research in …, 2017 - Springer
Background While several lines of evidence prove that elevated concentrations of low-
density lipoproteins (LDL) causally contribute to the development of atherosclerosis and its …

Is a high HDL-cholesterol level always beneficial?

B Franczyk, J Rysz, J Ławiński, M Rysz-Górzyńska… - Biomedicines, 2021 - mdpi.com
The specific interest concerning HDL cholesterol (HDL-C) is related to its ability to uptake
and return surplus cholesterol from peripheral tissues back to the liver and, therefore, to its …

HDL cholesterol and protective factors in atherosclerosis

G Assmann, AM Gotto Jr - Circulation, 2004 - Am Heart Assoc
A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for
cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C …

[PDF][PDF] Dysfunctional HDL: from structure-function-relationships to biomarkers

M Riwanto, L Rohrer, A von Eckardstein… - High Density …, 2015 - library.oapen.org
Reduced plasma levels of HDL-C are associated with an increased risk of CAD and
myocardial infarction, as shown in various prospective population studies. However, recent …

HDL-C: role as a risk modifier

P Barter - Atherosclerosis supplements, 2011 - Elsevier
Evidence that low-density lipoprotein-cholesterol (LDL-C) causes cardiovascular disease
(CVD) is overwhelming. It has also been proven beyond all doubt that lowering the level of …

The changing face of HDL and the best way to measure it

SK Karathanasis, LA Freeman, SM Gordon… - Clinical …, 2017 - academic.oup.com
Abstract BACKGROUND HDL cholesterol (HDL-C) is a commonly used lipid biomarker for
assessing cardiovascular health. While a central focus has been placed on the role of HDL …

HDL and cardiovascular risk: time to call the plumber?

B Hewing, KJ Moore, EA Fisher - Circulation research, 2012 - Am Heart Assoc
High-density lipoprotein cholesterol (HDL-C) has been dubbed the good cholesterol
because it is thought to reflect the ability of HDL particles to remove excess cholesterol …

HDL: the metabolism, function, and therapeutic importance

M Wang, MR Briggs - Chemical reviews, 2004 - ACS Publications
Epidemiological studies point to an inverse relationship between high-density lipoprotein
(HDL) levels and the risk of coronary artery disease (CAD). 1-5 Clinical trials such as the …

HDL particle number and size as predictors of cardiovascular disease

A Kontush - Frontiers in pharmacology, 2015 - frontiersin.org
Previous studies indicate that reduced concentrations of circulating high-density lipoprotein
(HDL) particles can be superior to HDL-cholesterol (HDL-C) levels as a predictor of …

Cardiovascular disease risk reduction by raising HDL cholesterol–current therapies and future opportunities

KM Ali, A Wonnerth, K Huber… - British journal of …, 2012 - Wiley Online Library
Since the first discovery of an inverse correlation between high‐density lipoprotein‐
cholesterol (HDL‐C) levels and coronary heart disease in the 1950s the life cycle of HDL, its …