IL-10 is an important immunoregulatory cytokine that plays a central role in maintaining a
balance between protective immunity against infection and limiting proinflammatory …

We recently constructed IL‐15 transgenic (Tg) mice using cDNA encoding a secretable
isoform of the IL‐15 precursor protein under the control of an MHC class I promoter. The IL …

Listeria monocytogenes infection induces a strong inflammatory response characterized by
the production of IL-12 and IFN-γ and protective immunity against this pathogen is …

Memory CD8 T cells play a critical role in providing protection to immune hosts by
orchestrating rapid elimination of pathogen-infected cells after re-infection. Systemic …

CD8 T cells play a critical role in the control and eradication of intracellular pathogens.
Increased understanding of CD8 T cell biology provides insight that can be translated into …

Various signals during infection influence CD8 T cell memory generation, but these factors
have yet to be fully defined. IL-12 is a proinflammatory cytokine that has been shown to …

Expression of IL-7Rα (CD127) has been suggested as a major determinant in the survival of
memory T cell precursors. We investigated whether constitutive expression of IL-7Rα on T …

Regulation of CD8 T cell expansion and contraction is essential for successful immune
defense against intracellular pathogens. IL-10 is a regulatory cytokine that can restrict T cell …

CD4 T cells are known to assist the CD8 T cell response by activating APC via CD40-CD40
ligand (L) interactions. However, recent data have shown that bacterial products can directly …

Interferon (IFN)-γ plays an important role in the innate immune response against intracellular
bacterial pathogens. It is commonly thought that natural killer cells are the primary source of …