Inflammation can have both positive and negative effects on development of CD8 T cell
memory, but the relative contributions and cellular targets of the cytokines involved are …

To study the role of IL‐12 as a third signal for T‐cell activation and differentiation in vivo,
direct IL‐12 signaling to CD8+ T cells was analyzed in bacterial and viral infections using …

CD8+ T cells are central to the eradication of intracellular pathogens, but they can also act to
limit inflammation and immunopathology. During primary respiratory viral infection CD8+ …

Listeria monocytogenes (Lm) infection induces robust CD8 T cell responses, which play a
critical role in resolving Lm during primary infection and provide protective immunity to re …

The role of CD8+ T cells in adaptive immunity is well documented and involves numerous
effector mechanisms including direct cytolysis of targets and secretion of cytokines. The role …

During many chronic infections virus-specific CD8 T cells succumb to exhaustion as they
lose their ability to respond to antigenic activation. Combinations of IL-12, IL-18, and IL-21 …

Infection of B6 mice with the intracellular pathogen Listeria monocytogenes (LM) results in
the activation of CD8+ T cells that respond to Ag presented by both MHC class Ia and class …

Mice with targeted mutations of CD18, the common β2 subunit of CD11/CD18 integrins,
have leukocytosis, impaired transendothelial neutrophil emigration, and reduced host …

The common γ chain cytokines interleukin (IL)-2 and IL-7 are important regulators of T cell
homeostasis. Although IL-2 is implicated in the acute phase of the T cell response, IL-7 is …

The relevance of direct inflammatory signals (signal 3) for the activation of memory CD8+ T
cells during recall responses is so far unknown. We therefore investigated the direct impact …