Despite evidence that morphine-related pathologies reflect adaptations in NAc glutamate
signaling, substantial gaps in basic information remain. The current study examines the …

Opiate withdrawal behaviors in the infant differ from those of the adult. The neural circuitry
underlying opioid withdrawal in the adult rat is well defined and includes the locus coeruleus …

The developing brain is extremely sensitive to drugs during adolescence. The devastating
impacts of opioid abuse in this critical period not only do involve individuals but also are …

Rationale: Neuroadaptations in the medial prefrontal cortex (mPFC) and Nucleus
Accumbens (NAc) play a role in the disruption of control-reward circuits in opioid addiction …

Glutamatergic signaling plays an important role in the behavioral and molecular plasticity
observed in behavioral sensitization to cocaine. Redistribution of the glutamate receptors in …

Background The incubation of cue-induced drug craving in rodents provides a model of
persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal …

Early life exposure to opiates may affect neuropathological conditions, such as epilepsy,
during adulthood. We investigated whether neonatal morphine exposure affects …

Cholinergic signaling is thought to be involved in morphine dependence and withdrawal, but
the specific mechanisms involved remain unclear. The current study aimed to identify …

Individuals with opioid use disorder (OUD) frequently use other substances, including
cocaine. Opioid withdrawal is associated with increased likelihood of cocaine use, which …

Individual differences in behavioral characteristics or initial responses to abused drugs had
been recently demonstrated to have predictive value in the propensity of later abuse. The …