Opioid abuse during pregnancy may have noteworthy effects on the child's behavioral,
emotional and cognitive progression. In this study, we assessed the effect of prenatal …

Precise control of synaptic strength is critical for maintaining accurate network activity and
normal brain functions. Several major brain diseases are related to synaptic alterations in …

Adaptive changes in brain areas following drug withdrawal are believed to contribute to drug
seeking and relapse. Cocaine withdrawal alters the expression of GluR1 and GluR2/3 …

Oxytocin attenuates cocaine-seeking when administered both systemically and directly into
the nucleus accumbens core. This effect is blocked by intra-accumbens antagonism of …

In a study of a possible substrate underlying morphine addiction, we examined NMDA
receptor-mediated synaptic transmission of core nucleus accumbens neurons after chronic …

We investigated the ability of dextromethorphan, a clinically available NMDA receptor
antagonist, to attenuate the behaviors and the expression of c-fos mRNA associated with …

Addiction to the psychostimulant Methamphetamine (METH) is characterised by high rates of
relapse. Currently there are no approved effective pharmacotherapies for METH …

Enhanced excitatory neurotransmission in the mesocorticolimbic system may contribute to
the persistence of addiction behaviour. Here, we demonstrated that glutamate-, N-methyl-d …

Advances in understanding the neurobiology of addiction indicate that not only
dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the …

Nucleus accumbens (NAc) neurons appear to be at the hub of the reward circuit. New
evidence suggests that the behavioural effects of morphine substances may be significantly …