Dysfunction of cell cycle control and defects of primary ciliogenesis are two features of many
cancers. Whether these events are interconnected and the driving mechanism coordinating …

Dynamic actin remodelling processes at the leading edge of migrating tumour cells are
concerted events controlled by a fine-tuned temporal and spatial interplay of kinases and …

The primary cilium is a microtubule‐based sensory organelle that dynamically links
signalling pathways to cell differentiation, growth, and development. Genetic defects of …

The primary cilium is a microtubule-based organelle that functions in sensory and signalling
pathways. Defects in ciliogenesis can lead to a group of genetic syndromes known as …

Oral-facial-digital (OFD) type I syndrome is an X-linked dominant disease (MIM311200)
characterized by malformations of oral cavity, face, and digits and by cystic kidneys. We …

Cdc42 plays a central role in regulating the actin cytoskeleton and maintaining cell polarity.
Here, we show that Cdc42 is crucial for epidermal growth factor (EGF)-stimulated protrusion …

The primary cilium has an important role in signaling; defects in structure are associated with
a variety of human diseases. Much of the most basic biology of this organelle is poorly …

Filopodia and lamellipodia are dynamic actin-based structures that determine cell shape
and migration. Filopodia are thought to sense the environment and direct processes such as …

Morphological plasticity in response to environmental cues in migrating cancer cells
requires F-actin cytoskeletal rearrangements. Conserved formin family proteins play critical …

Although the cancer cell cytoskeleton is a clinically validated target, few new strategies have
emerged for selectively targeting cell division by modulating the cytoskeletal structure …