The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It
is released under a variety of physiological and pathophysiological conditions to facilitate …

Unraveling the mystery of protein allostery has been one of the greatest challenges in both
structural and computational biology. However, recent advances in computational methods …

The concepts of allosteric modulation and biased agonism are revolutionizing modern
approaches to drug discovery, particularly in the field of G protein-coupled receptors …

The lack of biologically relevant protein structures can hinder rational design of small
molecules to target G protein-coupled receptors (GPCRs). While ensemble docking using …

Abstract Development of subtype-selective leads is essential in drug discovery campaigns
targeting G protein-coupled receptors (GPCRs). Herein, a structure-based virtual screening …

Significant progress has been made with stabilising G protein-coupled receptors (GPCRs) in
recent years, and this has enabled the structures of several members of this important target …

Over the past decade there has been a revolution in the field of G protein-coupled receptor
(GPCR) structural biology. Many years of innovative research from different areas have …

G protein-coupled receptors (GPCRs) represent the largest family of human membrane
proteins. Four subtypes of adenosine receptors (ARs), the A1AR, A2AAR, A2BAR and …

A new approach to generating information on ligand receptor interactions within the binding
pocket of G protein-coupled receptors has been developed, called Biophysical Mapping …

The association and dissociation kinetics of ligands binding to proteins vary considerably,
but the mechanisms behind this variability are poorly understood, limiting their utilization for …