Objective T lymphocytes play an important role in systemic sclerosis (SSc), a connective
tissue disease characterized by inflammation, fibrosis, and vascular damage. While their …

Objective Fibrosis is a major contributor to morbidity and mortality in systemic sclerosis
(SSc). T cells are the predominant inflammatory infiltrate in affected tissue and are thought to …

Objective Fibrotic skin changes in systemic sclerosis (SSc) are preceded by the appearance
of an inflammatory infiltrate rich in T cells. Since no direct comparison with T cells in normal …

Objective Despite the importance of interleukin‐13 (IL‐13) in systemic sclerosis (SSc) and
other fibrotic diseases, its mechanisms of action are not understood. We have reported that …

Objective To determine the potential clinical and pathological significance of altered
expression of interleukin 6 (IL-6) in systemic sclerosis (SSc). Methods Serum IL-6 and …

Background Abnormalities in lymphocyte surface markers and functions have been
described in systemic sclerosis (SSc), but conflicting results abound, and these studies often …

Objective To study the role of B lymphocytes in systemic sclerosis (SSc). Methods Peripheral
B cell subpopulations and the production of interleukin‐6 (IL‐6) and transforming growth …

Despite long-standing recognition of the importance of T cells in systemic sclerosis (SSc;
scleroderma), the role of CD8+ T cells in disease pathogenesis has not been well studied …

Objective The role of tumor necrosis factor (TNF) in systemic sclerosis (SSc) remains
controversial. The present study was undertaken to investigate the influence of TNF receptor …

Summary T helper 9 (Th9) cells and interleukin (IL)-9 are involved in the pathogenesis of
several autoimmune diseases. The exact role of IL-9 and Th9 cells in patients with systemic …