Dysregulation of type I interferons (IFNs) has been implicated in the pathogenesis of
systemic lupus erythematosus (SLE) since the late 1970s. The majority of SLE patients …

A significant body of data implicates the type I interferon (IFN) pathway in the pathogenesis
of autoimmune rheumatic diseases. In these disorders, a self-reinforcing cycle of IFN …

Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …

Type I IFN (IFN-I) was firstly described in 1957 as a soluble factor responsible for viral
resistance in vitro. Today, it is well known that the IFN-I family comprises a wide number of …

Highlights•Type I IFN is implicated in SLE pathogenesis by multiple lines of evidence,
including genetics and induction of SLE by IFN treatment.•Nucleic-acid sensing pathways …

Type I interferons, which make up the first cytokine family to be described and are the
essential mediators of antivirus host defense, have emerged as central elements in the …

In recent years, the study of systemic lupus erythematosus (SLE) patients has revealed a
central role for type I interferon (IFN) in disease pathogenesis. IFN induces the unabated …

▪ Abstract The significance of type I interferons (IFN-α/β) in biology and medicine renders
research on their activities continuously relevant to our understanding of normal and …

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease associated
with multiple immunologic abnormalities. Prominent among these is upregulation of type I …

Type I interferons (IFN) have long been recognised as mediators of innate immune defense
mechanisms against viral threats. Robust evidence over the last 15 years revealed their …