[HTML][HTML] Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity
Objective/methods DNA methylation plays an important role in obesity and related metabolic
complications. We examined genome-wide DNA promoter methylation along with mRNA …
complications. We examined genome-wide DNA promoter methylation along with mRNA …
[HTML][HTML] Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals
D Macartney-Coxson, MC Benton, R Blick… - Clinical …, 2017 - Springer
Background Epigenetic mechanisms provide an interface between environmental factors
and the genome and are known to play a role in complex diseases such as obesity. These …
and the genome and are known to play a role in complex diseases such as obesity. These …
Epigenome-wide association study of adiposity and future risk of obesity-related diseases
G Campanella, MJ Gunter, S Polidoro… - International journal of …, 2018 - nature.com
Background Obesity is an established risk factor for several common chronic diseases such
as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the …
as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the …
[HTML][HTML] An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss
Background Environmental factors can influence obesity by epigenetic mechanisms.
Adipose tissue plays a key role in obesity-related metabolic dysfunction, and gastric bypass …
Adipose tissue plays a key role in obesity-related metabolic dysfunction, and gastric bypass …
The epigenomic analysis of human obesity
CG Bell - Obesity, 2017 - Wiley Online Library
Objective Analysis of the epigenome—the chemical modifications and packaging of the
genome that can influence or indicate its activity—enables molecular insight into cell type …
genome that can influence or indicate its activity—enables molecular insight into cell type …
[HTML][HTML] The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Background Obesity is associated with changes in fat cell gene expression and metabolism.
What drives these changes is not well understood. We aimed to explore fat cell epigenetics …
What drives these changes is not well understood. We aimed to explore fat cell epigenetics …
[HTML][HTML] Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes
Background Obesity is a well-recognized risk factor for insulin resistance and type 2
diabetes (T2D), although the precise mechanisms underlying the relationship remain …
diabetes (T2D), although the precise mechanisms underlying the relationship remain …
Epigenome-wide association in adipose tissue from the METSIM cohort
Most epigenome-wide association studies to date have been conducted in blood. However,
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …
Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic …
Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …
diseases. However, the impact of these factors on the genome-wide DNA methylation …
Adiposity is associated with DNA methylation profile in adipose tissue
Background: Adiposity is a risk factor for type 2 diabetes and cardiovascular disease,
suggesting an important role for adipose tissue in the development of these conditions. The …
suggesting an important role for adipose tissue in the development of these conditions. The …