[HTML][HTML] GWAS on family history of Alzheimer's disease

RE Marioni, SE Harris, Q Zhang, AF McRae… - Translational …, 2018 - nature.com
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction
currently revolves around lifestyle changes with much research trying to elucidate the …

[HTML][HTML] Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild cognitive impairment

X Hu, EH Pickering, SK Hall, S Naik, YC Liu… - Translational …, 2011 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia among the elderly population;
however, knowledge about genetic risk factors involved in disease progression is limited …

[HTML][HTML] Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer's disease risk

D Shigemizu, R Mitsumori, S Akiyama… - Translational …, 2021 - nature.com
Alzheimer's disease (AD) has no cure, but early detection and risk prediction could allow
earlier intervention. Genetic risk factors may differ between ethnic populations. To discover …

[HTML][HTML] Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks

KE Tansey, D Cameron, MJ Hill - Genome medicine, 2018 - Springer
Background Genome-wide association studies of Alzheimer's disease (AD) have identified a
number of significant risk loci, the majority of which lie in non-coding regions of the genome …

Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk

V Moskvina, D Harold, GC Russo, A Vedernikov… - JAMA …, 2013 - jamanetwork.com
Importance Despite Alzheimer disease (AD) and Parkinson disease (PD) being clinically
distinct entities, there is a possibility of a pathological overlap, with some genome-wide …

African ancestry GWAS of dementia in a large military cohort identifies significant risk loci

R Sherva, R Zhang, N Sahelijo, G Jun, T Anglin… - Molecular …, 2023 - nature.com
While genome wide association studies (GWASs) of Alzheimer's Disease (AD) in European
(EUR) ancestry cohorts have identified approximately 83 potentially independent AD risk …

[HTML][HTML] Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p. Glu280Ala Alzheimer's disease

JI Vélez, SC Chandrasekharappa, E Henao… - Molecular …, 2013 - nature.com
The literature on GWAS (genome-wide association studies) data suggests that very large
sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect …

Behavioral and psychological symptoms in Alzheimer's disease

XL Li, N Hu, MS Tan, JT Yu… - BioMed research …, 2014 - Wiley Online Library
Neuropsychiatric symptoms (NPS) such as depression, apathy, aggression, and psychosis
are now recognized as core features of Alzheimer's disease (AD), and there is a general …

[HTML][HTML] Alzheimer's disease: analyzing the missing heritability

PG Ridge, S Mukherjee, PK Crane, JSK Kauwe… - PloS one, 2013 - journals.plos.org
Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic
factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide …

[HTML][HTML] Novel Alzheimer's disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers

JH Park, I Park, EM Youm, S Lee, JH Park, J Lee… - Translational …, 2021 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with a
complex genetic etiology. Besides the apolipoprotein E ε4 (APOE ε4) allele, a few dozen …