After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

The risk of Alzheimer's disease (AD) is strongly determined by genetic factors and recent
genome-wide association studies (GWAS) have identified several genes for the disease risk …

Typical, later-onset forms of Alzheimer's disease (AD) appear to be influenced by multiple
susceptibility loci, combinations of which contribute to the development of this disorder. We …

Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …

Depression is one of the most frequent psychiatric symptoms observed in people during the
development of Alzheimer's disease (AD). We hypothesized that genetic factors conferring …

Alzheimer's disease (AD) and related dementias are a major public health challenge and
present a therapeutic imperative for which we need additional insight into molecular …

Objective To identify single-nucleotide polymorphisms (SNPs) associated with risk and age
at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs …

Polygenic risk scores (PRSs) have been used to combine the effects of variants with small
effects identified by genome-wide association studies. We explore the potential for using …

Categorizing people with late-onset Alzheimer's disease into biologically coherent
subgroups is important for personalized medicine. We evaluated data from five studies (total …