Quantitation of DNA adducts in human tissues has been achieved with highly sensitive
techniques based on adduct radiolabeling, antisera specific for DNA adducts or modified …

To elucidate the relationship between DNA adduct formation and tumorigenesis, a number
of experiments have been conducted to measure DNA adducts in target tissues from …

Human DNA adduct formation (covalent modification of DNA with chemical carcinogens) is a
promising biomarker for elucidating the molecular epidemiology of cancer. Classes of …

Antisera elicited against carcinogen-DNA adducts and carcinogenmodified DNA samples
have been widely used in immunoassays and immunohistochemically to investigate …

Carcinogen DNA and protein adducts promise to provide a more objective measure of
human exposure to environmental carcinogens than can be obtained by questionnaire data …

The formation of deoxyribonucleic acid (DNA) adducts can have important and adverse
consequences for cellular and whole organism function. Available methods for identification …

I. INTRODUCTION Measurement of carcinogen-DNA adducts as a means of monitoring
human exposure to environmental and occupational carcinogens has become possible with …

A workshop was held to discuss the uses of data on DNA adduct measurement in humans
and in experimental systemsin vitroandin vivo. The discussions focused principally on the …

Over two centuries ago, Sir Percival Pott, a London surgeon, published a pioneering treatise
showing that soot exposure was the cause of high incidences of scrotal cancers occurring in …

Genotoxic carcinogens initiate the carcinogenic process in mammalian cells by damaging
DNA. Where the damage results in attachment of the carcinogen, or its activated metabolite …