Here, we interrogated head and neck cancer (HNSCC) specimens (n= 12) to examine if
different metabolic compartments (oxidative vs. glycolytic) co-exist in human tumors. A large …

Here, we developed a model system to evaluate the metabolic effects of oncogene (s) on the
host microenvironment. A matched set of “normal” and oncogenically transformed epithelial …

Objectives To explore metabolic symbiosis in gastric cancer and its relationship with cancer
prognosis. Patients and methods Immunohistochemistry was used to detect MCT4 and …

Background. Metabolism in the tumor microenvironment can play a critical role in
tumorigenesis and tumor aggression. Metabolic coupling may occur between tumor …

Recently, we proposed a new mechanism for understanding the Warburg effect in cancer
metabolism. In this new paradigm, cancer-associated fibroblasts undergo aerobic glycolysis …

Mitochondrial activity is a critical component of tumor metabolism, with profound implications
for tumorigenesis and treatment response. We analyzed clinical, genomic and expression …

We have recently proposed a new model of cancer metabolism to explain the role of aerobic
glycolysis and L-lactate production in fueling tumor growth and metastasis. In this model …

Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their
biosynthetic needs. Although the major determinants of this metabolic transformation have …

Monocarboxylate transporters (MCT) modulate tumor cell metabolism and offer promising
therapeutic targets for cancer treatment. Understanding the impact of MCT blockade on …

Despite advancements in cancer management, tumor relapse and metastasis are
associated with poor outcomes in many cancers. Over the past decade, oncogene-driven …