Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central
nervous system, serving as guidance cues during development and modulating synaptic …

The extracellular matrix of the central nervous system is an interconnected network of
proteins and sugars. It is crucial for homeostasis, but its remodeling in neurological diseases …

Introduction 3. CS proteoglycans and biosynthesis of CS 3.1. Structure of CS proteoglycans
3.2. Biosynthesis and structure of CS 4. Functional significance of structural variation of CS …

The brain extracellular matrix (ECM) is involved in several aspects of neuronal development,
plasticity, and pathophysiology. Chondroitin sulfate proteoglycans (CSPGs), consisting of …

Neural extracellular matrix (ECM) is different from the normal ECM in other organs in that it
has low fibrous protein content and high carbohydrate content. One of the key carbohydrate …

The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …

Proteoglycans are a heterogeneous class of proteins bearing sulfated glycosaminoglycans.
Some of the proteoglycans have distinct core protein structures, and others display …

Chondroitin sulfate proteoglycans (CSPGs) play important roles in the developing and
mature nervous system, where they guide axons, maintain stable connections, restrict …

Proteoglycans influence aging and plasticity in the nervous system. Particularly prominent
are the chondroitin sulfate proteoglycans (CSPGs), which are generally inhibitory to neurite …

Astrocytes modulate many aspects of neuronal function, including synapse formation and
the response to injury. Heparan sulfate proteoglycans (HSPGs) mediate some of the effects …