Brain chondroitin/dermatan sulfate, from cerebral tissue to fine structure: extraction, preparation, and fully automated chip-electrospray mass spectrometric analysis

AD Zamfir, C Flangea, A Serb, E Sisu… - … : Methods and Protocols, 2012 - Springer
Chondroitin sulfate (CS) and dermatan sulfate (DS) glycosaminoglycans (GAGs) are
covalently linked to proteins, building up a wide range of proteoglycans, with a prevalent …

Mass spectrometric analysis of chondroitin sulfate-linked peptides

MG Ramarajan, M Saraswat, R Budhraja… - Journal of Proteins and …, 2022 - Springer
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix components composed
of linear glycosaminoglycan (GAG) side chains attached to a core protein. CSPGs play a …

Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration

S Yang, S Hilton, JN Alves, LM Saksida, T Bussey… - Neurobiology of …, 2017 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs) are the main active component of perineuronal
nets (PNNs). Digestion of the glycosaminoglycan chains of CSPGs with chondroitinase ABC …

Heparan sulfate proteoglycans at a glance

CA Kirkpatrick, SB Selleck - Journal of cell science, 2007 - journals.biologists.com
Proteoglycans are abundant components of the cell surface and extracellular matrix that
mediate critical interactions between cells and their environment. They play a variety of …

Structural variation of chondroitin sulfate and its roles in the central nervous system

N Maeda - Central Nervous System Agents in Medicinal …, 2010 - ingentaconnect.com
Chondroitin sulfate is popular in the field of neuroscience, because the treatment of nervous
tissues with chondroitinase ABC, which degrades chondroitin sulfate up to unsaturated …

Involvement of chondroitin 6-sulfation in temporal lobe epilepsy

N Yutsudo, H Kitagawa - Experimental neurology, 2015 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs) are predominant components of the extracellular
matrix in the central nervous system (CNS). Previously, we found an increase in the 4 …

Exploring Heparan Sulfate Proteoglycans as Mediators of Human Mesenchymal Stem Cell Neurogenesis

SI Petersen, RK Okolicsanyi, LM Haupt - Cellular and molecular …, 2024 - Springer
Alzheimer's disease (AD) and traumatic brain injury (TBI) are major public health issues
worldwide, with over 38 million people living with AD and approximately 48 million people …

Chondroitin sulfate proteoglycans are a common component of neuronal inclusions and astrocytic reaction in neurodegenerative diseases

DA Dewitt, PL Richey, D Praprotnik, J Silver, G Perry - Brain research, 1994 - Elsevier
Previously, we showed three differentially sulfated forms of chondroitin sulfate proteoglycans
(CSPG) associated with senile plaques, astrocytes and neurofibrillary tangles in Alzheimer's …

[HTML][HTML] Sugar codes for axons?

CE Holt, BJ Dickson - Neuron, 2005 - cell.com
Proteoglycans are complex macromolecules with the potential for extraordinary diversity.
Several recent studies have demonstrated important roles for heparan sulfate and …

Spatiotemporal expression patterns of chondroitin sulfate proteoglycan mRNAs in the developing rat brain

R Gao, M Wang, J Lin, L Hu, Z Li, C Chen, L Yuan - Neuroreport, 2018 - journals.lww.com
Chondroitin sulfate proteoglycans (CSPGs) are pluripotent components of the extracellular
matrix in the brain. Although previous studies have examined the developmental change in …