Chondroitin sulfate proteoglycans (CSPGs) are a key structural component of the brain
extracellular matrix. They are involved in critical neurodevelopmental functions and are one …

Many chondroitin sulfate proteoglycans (CSPGs) have been shown to influence CNS axon
growth in vitro and in vivo. These interactions can be mediated through the core protein or …

Chondroitin sulfate proteoglycans are major constituents of the extracellular matrix and form
perineuronal nets. Information regarding the growth-inhibitory activity of these molecules …

Development of the mammalian nervous system involves generation of neurons from neural
stem cells, migration of generated neurons toward genetically determined locations …

There is increasing evidence that proteoglycans, particularly chondroitin sulfate
proteoglycans (CSPGs), are integral components in the assembly of the extracellular matrix …

Many neurons and their synapses are enwrapped in a brain-specific form of the extracellular
matrix (ECM), the so-called perineuronal net (PNN). It forms late in the postnatal …

Prion-like propagation of protein aggregates is thought to be an essential feature in many
neurodegenerative diseases, but the mechanisms underlying transcellular transfer of protein …

A wide variety of diseases throughout the mammalian organism is characterized by
abnormal deposition of various components of the extracellular matrix (ECM), including the …

Glycosaminoglycans (GAGs) with electrophoretic mobilities on cellulose acetate similar to
heparin (H), heparan sulfate (HS), and chondroitin sulfate (CS) were detected in cell extracts …

Previous studies have reported that heparan sulfate proteoglycans (HSPGs) promote
amyloid-beta peptide and tau fibrillization in Alzheimer disease (AD) and provide resistance …