Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa

JR Dettman, N Rodrigue, SD Aaron… - Proceedings of the …, 2013 - National Acad Sciences
Pseudomonas aeruginosa is an opportunistic pathogen of humans and is a major cause of
morbidity and mortality in patients with cystic fibrosis (CF). Prolonged infection of the …

Evolutionary Genomics of Niche-Specific Adaptation to the Cystic Fibrosis Lung in Pseudomonas aeruginosa

JR Dettman, R Kassen - Molecular biology and evolution, 2021 - academic.oup.com
The comparative genomics of the transition of the opportunistic pathogen Pseudomonas
aeruginosa from a free-living environmental strain to one that causes chronic infection in the …

Genome evolution drives transcriptomic and phenotypic adaptation in Pseudomonas aeruginosa during 20 years of infection

SJT Wardell, J Gauthier, LW Martin… - Microbial …, 2021 - microbiologyresearch.org
The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lungs of
patients with cystic fibrosis (CF). During infection the bacteria evolve and adapt to the lung …

Divergent, Coexisting Pseudomonas aeruginosa Lineages in Chronic Cystic Fibrosis Lung Infections

D Williams, B Evans, S Haldenby… - American journal of …, 2015 - atsjournals.org
Rationale: Pseudomonas aeruginosa, the predominant cause of chronic airway infections of
patients with cystic fibrosis, exhibits extensive phenotypic diversity among isolates within …

Evolutionary insight from Whole-Genome Sequencing of Pseudomonas Aeruginosa from Cystic Fibrosis Patients

RL Marvig, LM Sommer, L Jelsbak, S Molin… - Future …, 2015 - Taylor & Francis
The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in
patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality …

Dynamics of Pseudomonas aeruginosa genome evolution

K Mathee, G Narasimhan, C Valdes… - Proceedings of the …, 2008 - National Acad Sciences
One of the hallmarks of the Gram-negative bacterium Pseudomonas aeruginosa is its ability
to thrive in diverse environments that includes humans with a variety of debilitating diseases …

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Parallel Evolution in Pseudomonas aeruginosa over 39,000 Generations In Vivo

HK Huse, T Kwon, JEA Zlosnik, DP Speert… - MBio, 2010 - Am Soc Microbiol
ABSTRACT The Gram-negative bacterium Pseudomonas aeruginosa is a common cause of
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …

Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients

RL Marvig, D Dolce, LM Sommer, B Petersen, O Ciofu… - BMC microbiology, 2015 - Springer
Abstract Background Chronic infection with Pseudomonas aeruginosa is a major cause of
morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of …

Genome-Wide Patterns of Recombination in the Opportunistic Human Pathogen Pseudomonas aeruginosa

JR Dettman, N Rodrigue… - Genome biology and …, 2015 - academic.oup.com
The bacterium Pseudomonas aeruginosa is a significant cause of acute nosocomial
infections as well as chronic respiratory infections in patients with cystic fibrosis (CF). Recent …