Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-κB, STAT1/3, and Akt signaling pathways

F Xie, H Zhang, C Zheng, XF Shen - International Immunopharmacology, 2020 - Elsevier
Costunolide (CTL) is the major sesquiterpene lactone from Radix Aucklandiae, which is
widely used on the treatment of gastrointestinal diseases. However, the therapeutic effect of …

Costunolide ameliorates colitis via specific inhibition of HIF1α/glycolysis-mediated Th17 differentiation

Q Lv, Y Xing, D Dong, Y Hu, Q Chen, L Zhai… - International …, 2021 - Elsevier
Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder of colon. Costunolide,
the main active constituent of Radix Aucklandiae, has been demonstrated to possess anti …

Andrographolide derivative CX-10 ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: involvement of NF-κB and MAPK signalling pathways

Z Gao, C Yu, H Liang, X Wang, Y Liu, X Li, K Ji… - International …, 2018 - Elsevier
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized
by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are …

Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice

P Li, M Wu, W Xiong, J Li, Y An, J Ren, Y Xie… - International …, 2020 - Elsevier
Abstract Saikosaponin-d (SSd), extracts from Bupleurum falcatum L, exhibits anti-
inflammatory and anti-infectious activities. However, the effect of SSd on intestinal …

[HTML][HTML] NF-κB and Nrf2 pathways contribute to the protective effect of Licochalcone A on dextran sulphate sodium-induced ulcerative colitis in mice

D Liu, X Huo, L Gao, J Zhang, H Ni, L Cao - Biomedicine & …, 2018 - Elsevier
Abstract Licochalcone A (Lico A) is a characteristic chalcone isolated from licorice root which
is widely recognized in traditional Chinese medicine for the ability of anti-inflammatory …

Sesquiterpene lactones-rich fraction from Aucklandia lappa Decne. alleviates dextran sulfate sodium induced ulcerative colitis through co-regulating MAPK and Nrf2 …

Y Chen, Z Miao, X Sheng, X Li, J Ma, X Xu, H Li… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Aucklandia lappa Decne.(ALDE) is the general
name for Asteraceae plants Yunmuxiang, which has traditionally been proven to have the …

The Possible Anti‐Inflammatory Effect of Dehydrocostus Lactone on DSS‐Induced Colitis in Mice

Q Zhou, W Zhang, Z He, B Wu, Z Shen… - Evidence‐Based …, 2020 - Wiley Online Library
Background. Dehydrocostus lactone (DL), one of the main active constituents in Aucklandia
lappa Decne.(Muxiang), reported to have anti‐inflammatory, antiulcer, and …

Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation

Y Sun, Y Zhao, J Yao, L Zhao, Z Wu, Y Wang… - Biochemical …, 2015 - Elsevier
Previous studies have demonstrated that wogonoside, the glucuronide metabolite of
wogonin, has anti-inflammatory, anti-angiogenic and anticancer effects. However, the anti …

Dehydrocostus lactone suppresses dextran sulfate sodium-induced colitis by targeting the IKKα/β-NF-κB and Keap1-Nrf2 signalling pathways

Y Yuan, Q Hu, L Liu, F Xie, L Yang, Y Li… - Frontiers in …, 2022 - frontiersin.org
Dehydrocostus lactone (DCL) is a major sesquiterpene lactone isolated from Aucklandia
lappa Decne, a traditional Chinese herbal medicine that used to treat gastrointestinal …

Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway

H Zhang, W Lang, S Li, C Xu, X Wang, Y Li… - …, 2023 - Taylor & Francis
Objective Corynoline is an active substance extracted from Corydalis bungeana Turcz and
exerts a therapeutic effect in multiple diseases by alleviating inflammatory response. The …