Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …

Objective Minocycline is known to reduce microglial activation, suggesting that it may reduce
neuropathic pain. We reviewed studies in humans that evaluated the effectiveness of …

Tetracyclines are natural or semi-synthetic bacteriostatic agents which have been used
since late 1940s against a wide range of gram-positive and gram-negative bacteria and …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …

Recent understanding of the neuron–glia communication shed light on an important role of
microglia to develop neuropathic pain The analgesic effect of minocycline on neuropathic …

Background: Less than 50% of patients experience sufficient pain relief with current drug
therapy for neuropathic pain. Minocycline shows promising results in rodent models of …

Aim: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …

The present study investigates the analgesic effect of minocycline, a semi-synthetic
tetracycline antibiotic, in a rat model of inflammation-induced visceral pain. Inflammation …

Background: Evidence indicates that neuropathic pain pathogenesis is not confined to
changes in the activity of neuronal systems but involves interactions between neurons …

Many studies have shown that minocycline, an antibacterial tetracycline, suppresses
experimental pain. While minocycline's positive effects on pain resolution suggest that …