Neuropathic pain is an intractable clinical problem, affecting millions of people worldwide.
Preemptive administration of minocycline has been confirmed useful for treating neuropathic …

Background: The molecular mechanisms underlying neuropathic pain are constantly being
studied to create new opportunities to prevent or alleviate neuropathic pain. The aim of our …

Background: Minocycline prevents the development of neuropathic and inflammatory pain
by inhibiting microglial activation and postsynaptic currents. But, how minocycline obviates …

Rationale Minocycline, a tetracycline antibiotic, inhibits activation of microglia. In preclinical
studies, minocycline prevented development of opioid tolerance and opioid-induced …

Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …

Objective (s): Several lines of evidence showed that minocycline possesses antioxidant and
anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in …

It has been demonstrated that spinal microglial activation is involved in formalin-induced
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …

Neuropathic pain is a challenge for physicians and basic science researchers, because it
often does not respond to routine treatment. The administration of morphine has been …

Background: Minocycline has proven anti-nociceptive effects, but the mechanism by which
minocycline delays the development of allodynia and hyperalgesia after peripheral nerve …

We have previously demonstrated that activation of p38 mitogen-activated protein kinase
(p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance …