Repeated injections of the antibiotic ceftriaxone cause analgesia in rodents by upregulating
the glutamate transporter, GLT-1. No evidence is available in humans. We studied the effect …

Pain is an unpleasant sensory and emotional experience associated with various diseases.
Extensive research has been conducted to find appropriate methods of relieving pain and …

Repeated and long-term administration of opioids is often accompanied by the initiation of
opioid-induced analgesic tolerance and hyperalgesia in chronic pain patients. Our previous …

Background: Oxaliplatin is an important drug used in the treatment of colorectal cancer.
However, it frequently causes severe acute and chronic peripheral neuropathies. We …

Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic
neuropathies in patients. Amitriptyline has widely been used in patients with painful …

Background Neuropathic pain, a chronic condition with a high incidence, imposes
psychological burdens on both patients and society. It is urgent to improve pain …

Metformin, an AMP-activated protein kinase (AMPK) activator, is an oral hypoglycemic drug
widely used to treat patients with type 2 diabetes. As AMPK plays a role in the nociceptive …

Neuropathic pain can have a major effect on quality of life but current therapies are often
inadequate. Growing evidence suggests that neuropathic pain induced by nerve damage is …

Paclitaxel (Taxol®) is one of the most effective and frequently used chemotherapeutics for
the treatment of solid tumours. However, paclitaxel produces peripheral neurotoxicity with …

Pharmacological interventions to treat psychiatric illness have previously focused on
modifying dysfunctional neurotransmitter systems to improve symptoms. However, imperfect …