Maternal infection and schizophrenia: implications for prevention

AS Brown, PH Patterson - Schizophrenia bulletin, 2011 - academic.oup.com
Accumulating evidence suggests that maternal infection is a risk factor for schizophrenia.
Prospective epidemiological studies indicate that maternal influenza, toxoplasmosis, and …

Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence

L Farrelly, M Föcking, Y Piontkewitz, P Dicker… - Developmental …, 2015 - karger.com
Background: Maternal infection is a risk factor for schizophrenia but the molecular and
cellular mechanisms are not fully known. Myelin abnormalities are amongst the most robust …

Prenatal inflammation, infections and mental disorders

E Flinkkilä, A Keski-Rahkonen, M Marttunen… - …, 2016 - karger.com
Background: The objective of this descriptive review is to summarize the current scientific
evidence on the effect of prenatal exposure to maternal infection and immune response on …

Altered dendritic morphology in dorsolateral prefrontal cortex of nonhuman primates prenatally exposed to maternal immune activation

KL Hanson, RK Weir, AM Iosif, J Van de Water… - Brain, behavior, and …, 2023 - Elsevier
Women who contract a viral or bacterial infection during pregnancy have an increased risk
of giving birth to a child with a neurodevelopmental or psychiatric disorder. The effects of …

Epigenetic and transgenerational mechanisms in infection-mediated neurodevelopmental disorders

U Weber-Stadlbauer - Translational psychiatry, 2017 - nature.com
Prenatal infection is an environmental risk factor for various brain disorders with
neurodevelopmental components, including autism spectrum disorder and schizophrenia …

Genome-wide transcriptional profiling and structural magnetic resonance imaging in the maternal immune activation model of neurodevelopmental disorders

J Richetto, R Chesters, A Cattaneo… - Cerebral …, 2017 - academic.oup.com
Prenatal exposure to maternal infection increases the risk of neurodevelopmental disorders,
including schizophrenia and autism. The molecular processes underlying this pathological …

Is there a flame in the brain in psychosis?

CS Carter, ET Bullmore… - Biological …, 2014 - biologicalpsychiatryjournal.com
Shatz and colleagues (1) reported in 2000 that a number of immune proteins (cytokines and
major histocompatibility complex [MHC] proteins) were not just present in the brain but were …

Schizophrenia associated sensory gating deficits develop after adolescent microglia activation

M Eßlinger, S Wachholz, MP Manitz, J Plümper… - Brain, behavior, and …, 2016 - Elsevier
Maternal infection during pregnancy is a well-established risk factor for schizophrenia in the
adult offspring. Consistently, prenatal Poly (I: C) treatment in mice has been validated to …

Molecular mechanisms underlying the models of neurodevelopmental disorders in maternal immune activation relevant to the placenta

T Tsukada, H Shimada, H Sakata‐Haga… - Congenital …, 2019 - Wiley Online Library
The rapid rise in the prevalence of autism spectrum disorders (ASD) and other psychiatric
disorders displaying similar traits has increased the need to elucidate their molecular …

Maternal immune activation in neurodevelopmental disorders

CM Solek, N Farooqi, M Verly, TK Lim… - Developmental …, 2018 - Wiley Online Library
Converging lines of evidence from basic science and clinical studies suggest a relationship
between maternal immune activation (MIA) and neurodevelopmental disorders such as …