Association between hospitalization for heart failure and dipeptidyl peptidase 4 inhibitors in patients with type 2 diabetes: an observational study

AZ Fu, SS Johnston, A Ghannam, K Tsai… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE To examine, among patients with type 2 diabetes, the association between
hospitalization for heart failure (hHF) and treatment with dipeptidyl peptidase 4 inhibitors …

The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone

RA DeFronzo, MN Hissa, AJ Garber… - Diabetes …, 2009 - Am Diabetes Assoc
OBJECTIVE This 24-week trial assessed the efficacy and safety of saxagliptin as add-on
therapy in patients with type 2 diabetes with inadequate glycemic control with metformin …

Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus

AA Tahrani, MK Piya, AH Barnett - Advances in therapy, 2009 - Springer
Type 2 diabetes mellitus (T2DM) is a global epidemic with increasing impact on individuals
and healthcare providers. Available treatments (such as metformin, sulfonylureas …

Influence of renal or hepatic impairment on the pharmacokinetics of saxagliptin

D Boulton, L Li, EU Frevert, A Tang, L Castaneda… - Clinical …, 2011 - Springer
Abstract Background and Objective Patients with type 2 diabetes mellitus often have
impaired renal function or may have impaired hepatic function, which can pose significant …

Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes

JB Green, MA Bethel, PW Armstrong… - … England Journal of …, 2015 - Mass Medical Soc
Background Data are lacking on the long-term effect on cardiovascular events of adding
sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes …

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Once-Daily Oral Doses of Saxagliptin for 2 Weeks in Type 2 Diabetic and Healthy Subjects.

DW Boulton, M Geraldes - Diabetes, 2007 - search.ebscohost.com
The objectives of the studies were to assess the safety, tolerability and the pharmacokinetic
(PK) and pharmacodynamic (PD) properties following 2 weeks of oral once-daily (QD) doses …

Saxagliptin vs. glipizide as add‐on therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: long‐term (52‐week) extension of a …

B Göke, B Gallwitz, JG Eriksson… - … journal of clinical …, 2013 - Wiley Online Library
Aim To compare the long‐term safety, tolerability and efficacy of saxagliptin vs. glipizide as
add‐on therapy to metformin. Methods Adults with glycated haemoglobin (HbA1c)> 6.5 …

Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus

AJ Scheen, G Charpentier, CJ Östgren… - Diabetes/metabolism …, 2010 - Wiley Online Library
Background Dipeptidyl peptidase‐4 inhibitors improve glycaemic control in patients with
type 2 diabetes mellitus when used as monotherapy or in combination with other anti …

Risk for hospitalized heart failure among new users of saxagliptin, sitagliptin, and other antihyperglycemic drugs: a retrospective cohort study

S Toh, C Hampp, ME Reichman… - Annals of internal …, 2016 - acpjournals.org
This article has been corrected. The original version (PDF) is appended to this article as a
Supplement. Background: Recent postmarketing trials produced conflicting results about the …

Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a …

AR Chacra, GH Tan, A Apanovitch… - … journal of clinical …, 2009 - Wiley Online Library
Aims: Assess the efficacy and safety of saxagliptin added to a submaximal sulphonylurea
dose vs. uptitration of sulphonylurea monotherapy in patients with type 2 diabetes and …