Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which
lays the foundation for gametogenesis, totipotency, and embryonic development. We …

Epigenetic reprogramming is a central process during mammalian germline development.
Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the …

Mouse primordial germ cells (PGCs) erase global DNA methylation (5mC) as part of the
comprehensive epigenetic reprogramming that occurs during PGC development. 5mC plays …

Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …

Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …

Germline cells reprogramme extensive epigenetic modifications to ensure the cellular
totipotency of subsequent generations and to prevent the accumulation of epimutations …

Epigenetic reprogramming in the germline resets genomic potential and erases epigenetic
memory. Three studies by Gkountela et al., Guo et al., and Tang et al. analyze the …

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …