Conspectus This Account describes fundamental chemistry that promoted the discovery of
new antibiotics. Specifically, the NH acidity of simple hydroxamic acid derivatives facilitated …

New or repurposed antibiotics are desperately needed since bacterial resistance has risen
to essentially all of our current antibiotics, and few new antibiotics have been developed …

The overuse of broad-spectrum antibiotics rapidly selects for dangerous multi-drug resistant
bacterial pathogens. The landscape of antibiotic drug discovery is adapting to this wave of …

The success of precision medicine coupled with the disappointing impact of broad-spectrum
antibiotic use on microbiome stability and bacterial resistance, has triggered a shift in …

Background Bacterial infections involving multidrug-resistant Gram-negative bacteria have
become critically involved in the current antibiotic crisis. This, together with the bacterial …

Antimicrobial resistance (AMR) is a global threat to society due to the increasing emergence
of multi-drug resistant bacteria that are not susceptible to our last line of defence antibiotics …

The increasing bacterial resistance from antibiotic overuse has fostered the search for novel
antimicrobial strategies. In particular, bacterial systems involving iron (Fe) uptake are …

Introduction: Since the first application of antibiotics to treat bacterial infections, the
development and spread of resistance has been a persistent threat. An ever evolving …

Multi-drug resistant infections caused by Gram-negative bacteria have become one of the
most important reasons for the failure of clinical anti-infective treatment. Siderophore …

Three siderophore–drug conjugates (sideromycins) were synthesized by preparation of a
maleimide linked derivative of the siderophore desferrioxamine B and reacting the …