Aster tataricus extract 100 and 500 mg/kg and silymarin 50 mg/kg groups, respectively).
Fibrosis was induced by thioacetamide treatment (200 mg/kg, ip) 3 times per week for 13 …

Aims Lysophosphatidic acid is a lipid mediator that is supposed to be implicated in hepatic
fibrosis. Silymarin and caffeine are natural compounds known for their anti-inflammatory and …

Oxidative stress caused hepatic fibrosis by activating hepatic stellate cells (HSCs), which
were implemented by depressing PPARγ activation. Hydroxysafflor yellow A (HSYA) as a …

Liver fibrosis is a grave problem worldwide, and the development of this condition is the first
step towards cirrhosis. In fact, when lesions of different aetiologies chronically affect the liver …

Liver fibrosis represents a frequent event following chronic insult to trigger wound healing
responses in the liver. Activation of hepatic stellate cells (HSCs), which is a pivotal event …

Liver fibrosis occurs due to liver injuries and toxins. Silymarin (SMR) extracted by the milk
thistle seeds, is widely used such as herbal drug for its hepatoprotective properties. The …

Hepatic fibrosis is one of the critical steps contained in the pathogenesis of liver cirrhosis.
Excessive deposition of collagen contributes to the development of fibrosis in chronic liver …

Hepatic stellate cells (HSC) play a key role in liver fibrogenesis. Activation of PPARγ and
inhibition of fibrogenic molecules are potential strategies to block HSC activation and …

Resveratrol is a naturally occurring polyphenol, possesses several pharmacological
activities including anticancer, antioxidant, antidiabetic, antinociceptive, and antiasthmatic …

Resveratrol (RSV) exerts anti-proliferative and pro-apoptotic actions in different cell lines.
Hepatic stellate cells (HSCs) are major fibrogenic cell types that contribute to collagen …