In both Crohn's disease (CD) and ulcerative colitis, the pathologic process is almost certainly
driven by an aberrant local immune response directed against normal components of the …

In the gut of patients with Crohn's disease and patients with ulcerative colitis, the major forms
of inflammatory bowel diseases (IBD) in humans, the tissue-damaging immune response is …

In both Crohn's disease (CD) and ulcerative colitis (UC), the major forms of inflammatory
bowel diseases (IBD) in humans, the pathologic process consists of an aberrant local …

In healthy individuals, antigens from the gut lumen are tolerated by the mucosal immune
system. However, a loss of tolerance toward the bacterial microflora probably causes …

Inflammatory bowel disease (IBD), typified by Crohn's disease and ulcerative colitis, is a
common disorder characterized by recurrent and serious inflammation of the gastrointestinal …

Background & Aims: Interleukin (IL)-21, a T-cell-derived cytokine, is overproduced in
inflammatory bowel diseases (IBD), but its role in the pathogenesis of gut inflammation …

Background We previously demonstrated that in inflammatory bowel disease (IBD) there is
enhanced production of interleukin (IL)-21, a cytokine that activates multiple pathways that …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases
(IBDs) occurring in the gut of genetically susceptible individuals independent of a specific …

The etiology of inflammatory bowel disease is unknown but available evidence suggests
that a deregulated immune response towards the commensal bacterial flora is responsible …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease thought to be mediated
by the microbiota of the intestinal lumen and inappropriate immune responses. Aberrant …