The pharmacokinetic parameters of MHGH 22K, such as the mean values of t 1 2 (9.30,
16.8, 22.2 vs 25.8 min), MRT (11.6, 21.7, 26.7 vs 37.9 min) and V ss (166, 218, 342 vs 556 …

Two forms of human GH (hGH) have been produced by recombinant DNA technology. One
form has an amino acid sequence identical to that of the natural pituitary hormone (rhGH) …

We compared the disappearance rate of hGH and hGH20K injected into groups of mice.
Radioactivity measurements and RIA were used to determine the amount of hormone in …

Abstract The 20,000-dalton variant of human GH (hGH)(20 K) exhibits full growth-promoting
bioactivity in the rat despite its poor interaction with GH receptors, as compared to the …

Using a combination of polyacrylamide gel electrophoresis in the presence of sodium
dodecyl sulfate and immunoblotting with antihuman GH (anti-hGH) serum, we quantitatively …

The pharmacokinetics, safety and endocrine effects of an authentic human growth hormone
(bio‐hGH), produced by the expression of genomic hGH in a mammalian cell line, were …

Escherichia coli cells transformed with plasmids engineered for the expression of
recombinant human growth hormone as a secreted product also produced a proteolytically …

Because of the propensity of the 20-kDa variant of human growth human (GH) to aggregate
with itself and with 22-kDa human GH, it has been difficult to prepare monomeric 20-kDa GH …

A radioimmunoassay (RIA) method was developed for determination of superactive GH-RH
agonist Dat1, Ala15, Nle27 GH-RH (1-28) Agm29 (MZ-2-51) and some of the related …

The efficient purification and characterization of the product of chemically synthesized
human growth hormone (hGH) gene expressed in Escherichia coli are described. The …