Expression, purification and characterization of the authentic form of human growth hormone receptor antagonist G120R-hGH obtained in Escherichia coli periplasmic …
ACSC Menezes, MF Suzuki, JE Oliveira… - Protein Expression and …, 2017 - Elsevier
The human growth hormone receptor antagonist G120R-hGH precludes dimerization of GH
and prolactin receptors and consequently JAK/STAT signaling. Some modifications in this …
and prolactin receptors and consequently JAK/STAT signaling. Some modifications in this …
Synthesis and purification of a deleted human growth hormone, hGHΔ135–146: sensitivity to plasmin cleavage and in vitro and in vivo bioactivities
KSM Alam, T Fujikawa, H Yoshizato, M Tanaka… - Journal of …, 2000 - Elsevier
Proteolytically cleaved human 22 kDa growth hormone (22K hGH) between the amino acid
residues 134 and 150 by plasmin or other proteases in vitro has been reported to be most …
residues 134 and 150 by plasmin or other proteases in vitro has been reported to be most …
Demonstration by Radioligand-Binding Assay of the Structural Similarity of a Partially Synthetic Growth Hormone Recombinant Molecule to Its Natural Analog and to …
S BURSTEIN, MM GRUMBACH… - The Journal of …, 1979 - academic.oup.com
The recombinant resulting from the noncovalent interaction of a natural amino-terminal
fragment of reduced and carbamoylmethylated human GH (residues 1–134) with a synthetic …
fragment of reduced and carbamoylmethylated human GH (residues 1–134) with a synthetic …
The synthetic human growth hormone fragment (32–38) increases glucose uptake in the conscious dog
RW Stevenson, N Stebbing, T Jones… - European Journal of …, 1988 - academic.oup.com
Abstract hGH32-38 was tested to determine if the peptide could affect hepatic glucose
production in the conscious dog under basal conditions (euglycemia) or if it could enhance …
production in the conscious dog under basal conditions (euglycemia) or if it could enhance …
Process development for downstream processing of human growth hormone and its antagonist
Y Zheng - 1994 - rave.ohiolink.edu
The goal of this work is to develop a downstream process for the purification of human
growth hormone (hGH) and an hGH antagonist, named hGHG120R, from cultured …
growth hormone (hGH) and an hGH antagonist, named hGHG120R, from cultured …
Pharmacokinetics and pharmacodynamics of a single dose of recombinant human growth hormone after subcutaneous administration by jet-injection: comparison …
A Verhagen, JT Ebels, JHG Jonkman… - European journal of …, 1995 - Springer
The pharmacokinetics and pharmacodynamics of recombinant human growth hormone
(rhGH) were studied after a single subcutaneous dose given by jet-injection, and have been …
(rhGH) were studied after a single subcutaneous dose given by jet-injection, and have been …
Subcutaneous absorption kinetics of two highly concentrated preparations of recombinant human growth hormone
T Laursen, JOL Jørgensen, S Susgaard, J Møller… - 1993 - journals.sagepub.com
OBJECTIVE: The relative bioavailability of two highly concentrated (12 IU/mL) formulations
of biosynthetic human growth hormone (GH) administered subcutaneously was compared …
of biosynthetic human growth hormone (GH) administered subcutaneously was compared …
In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone
O Hershkovitz, A Bar-Ilan, R Guy… - Molecular …, 2016 - ACS Publications
MOD-4023 is a novel long-acting version of human growth hormone (hGH), containing the
carboxy-terminal peptide (CTP) of human chorionic gonadotropin (hCG). MOD-4023 is …
carboxy-terminal peptide (CTP) of human chorionic gonadotropin (hCG). MOD-4023 is …
Activity of artificial mutant variants of human growth hormone deficient in a disulfide bond between Cys53 and Cys165
E UCHIDA, H UEMURA, T TANAKA… - Chemical and …, 1991 - jstage.jst.go.jp
抄録 In order to understand the role of Cys53 and Cys165 of human growth hormone (hGH)
in receptor-binding and biological activity, artificial mutant variants of hGH were prepared in …
in receptor-binding and biological activity, artificial mutant variants of hGH were prepared in …
Site-directed mutagenesis at 134/135 in human growth hormone alters its in vivo half-life in the rat.
M Morimoto, M Tanaka, K Nakashima - Biochemistry and molecular …, 1996 - europepmc.org
It has been shown that human growth hormone (hGH) is attacked and digested at Arg (134)-
Thr (135) by thrombin and plasmin, facilitating its further degradation in the plasma and …
Thr (135) by thrombin and plasmin, facilitating its further degradation in the plasma and …