The role of infection in chronic obstructive pulmonary disease (COPD) was first postulated in
1953 by Stuart-Harris and colleagues 1 in what is now known as the British hypothesis. They …

Most of the bacterial species isolated from sputum during exacerbations of chronic
obstructive pulmonary disease (COPD) colonize the nasopharynx of healthy individuals, and …

Copd, comprising emphysema and/or chronic bronchitis, with or without associated
bronchospasm, is a common malady in the United States. It has been estimated that up to 15 …

Clinical studies of acute exacerbations of COPD are difficult because of the heterogeneous
nature of COPD, diffuse symptoms that can vary spontaneously, and difficulties in defining …

Antibiotics are commonly prescribed empirically to patients presenting with an acute
exacerbation of chronic obstructive pulmonary disease (COPD) to treat presumed bacterial …

Background: Patients with chronic obstructive pulmonary disease (COPD) are prone to
frequent exacerbations which are a significant cause of morbidity and mortality. Stable …

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the
United States. The precise role of bacterial infection in the course and pathogenesis of …

The debate about the importance of bacterial infection in chronic obstructive pulmonary
disease will continue. About half of exacerbations yield positive sputum bacteriology, and …

We examined the risk factors for bacterial exacerbation, defined as the presence of
pathogenic bacteria in sputum, in 90 chronic obstructive pulmonary disease (COPD) …

Exacerbations of COPD, which include combinations of dyspnea, cough, wheezing,
increased sputum production (and a change in its color to green or yellow), are common …