Traumatic brain injury (TBI) is one of the leading causes of trauma-induced mortality and
disability, and emerging studies have shown that endoplasmic reticulum (ER) stress plays …

Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which
has been demonstrated to have neuroprotective effects in different neurological disease …

Objective: To explore themechanism of tauroursodeoxycholic acid-(TUDCA) mediated
neuronal protection after acute spinal cord injury (ASCI) in rats. Methods: ASCI rat model …

Spinal cord injury (SCI) is generally divided into primary and secondary injuries, and
apoptosis is an important event of the secondary injury. As an endogenous bile acid and …

Background Neuronal apoptosis plays a critical event in the pathogenesis of early brain
injury after subarachnoid hemorrhage (SAH). This study investigated the roles of …

The objective of this review was to evaluate the potential of tauroursodeoxycholic acid
(TUDCA) for neuroprotection in traumatic brain injury (TBI) patients in the neurocritical care …

Tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, modulates cell death by
interrupting classic pathways of apoptosis. Intracerebral hemorrhage (ICH) is a devastating …

Spinal cord injury (SCI) is a prevalent and significant injury to the central nervous system,
resulting in severe consequences. This injury is characterized by motor, sensory, and …

Background Bile acids are steroid acids found predominantly in the bile of mammals. The
bile acid conjugate tauroursodeoxycholic acid (TUDCA) is a neuroprotective agent in …

Early brain injury (EBI) has been recognized as a major cause of poor clinical outcomes in
patients with spontaneous subarachnoid hemorrhage (SAH). Endoplasmic reticulum (ER) …