Insights into the baicalein-induced destabilization of LS-shaped Aβ 42 protofibrils using computer simulations
G Kaur, OK Mankoo, A Kaur, D Goyal… - Physical Chemistry …, 2024 - pubs.rsc.org
Amyloid-β (Aβ) peptides aggregate spontaneously into various aggregating species
comprising oligomers, protofibrils, and mature fibrils in Alzheimer's disease (AD). Disrupting …
comprising oligomers, protofibrils, and mature fibrils in Alzheimer's disease (AD). Disrupting …
Destabilization of Alzheimers Amyloid-beta Protofibrils by Bai-calein: Mechanistic Insights from All-atom Molecular Dynamics Simulations
S Choudhury, AK Dasmahapatra - arXiv preprint arXiv:2406.04852, 2024 - arxiv.org
Alzheimer's disease (AD) is a neurodegenerative disorder; it is the most common form of de-
mentia and the fifth leading cause of death globally. Aggregation and deposition of …
mentia and the fifth leading cause of death globally. Aggregation and deposition of …
Destabilization of Alzheimer's Aβ42 protofibrils with a novel drug candidate wgx-50 by molecular dynamics simulations
Alzheimer's disease (AD) is one of the most common dementia. The aggregation and
deposition of the amyloid-β peptide (Aβ) in neural tissue is its characteristic symptom. To …
deposition of the amyloid-β peptide (Aβ) in neural tissue is its characteristic symptom. To …
Dissecting the Inhibitory Mechanism of the αB-Crystallin Domain against Aβ42 Aggregation and Its Effect on Aβ42 Protofibrils: A Molecular Dynamics Simulation …
Z Xu, Y Gong, Y Zou, J Wan, J Tang… - ACS Chemical …, 2022 - ACS Publications
Alzheimer′ s disease (AD) is related to the misfolding and aggregation of amyloid-β (Aβ)
protein, and its major pathological hallmark is fibrillary β-amyloid plaques. Impeding the …
protein, and its major pathological hallmark is fibrillary β-amyloid plaques. Impeding the …
9, 10‐Anthraquinone hinders β‐aggregation: How does a small molecule interfere with Aβ‐peptide amyloid fibrillation?
M Convertino, R Pellarin, M Catto, A Carotti… - Protein …, 2009 - Wiley Online Library
Amyloid aggregation is linked to a number of neurodegenerative syndromes, the most
prevalent one being Alzheimer's disease. In this pathology, the β‐amyloid peptides (Aβ) …
prevalent one being Alzheimer's disease. In this pathology, the β‐amyloid peptides (Aβ) …
Mechanistic insight into E22Q-mutation-induced antiparallel-to-parallel β-sheet transition of Aβ 16− 22 fibrils: an all-atom simulation study
Alzheimer's disease is associated with the abnormal self-assembly of amyloid-β (Aβ)
peptide into toxic oligomers and fibrils. Recent experiments reported that Aβ16− 22 …
peptide into toxic oligomers and fibrils. Recent experiments reported that Aβ16− 22 …
Norepinephrine inhibits Alzheimer's amyloid-β peptide aggregation and destabilizes amyloid-β protofibrils: A molecular dynamics simulation study
The abnormal self-assembly of amyloid-β (Aβ) peptides into toxic fibrillar aggregates is
associated with the pathogenesis of Alzheimer's disease (AD). The inhibition of β-sheet-rich …
associated with the pathogenesis of Alzheimer's disease (AD). The inhibition of β-sheet-rich …
Insights into the Inhibitory Mechanism of Dicyanovinyl‐Substituted J147 Derivative against Aβ42 Aggregation and Protofibril Destabilization: A Molecular Dynamics …
The self‐assembly of amyloid β‐peptide (Aβ) into β‐sheet enriched fibrillar aggregates is
associated with Alzheimer's disease (AD). A disease modifying therapy for AD involves a …
associated with Alzheimer's disease (AD). A disease modifying therapy for AD involves a …
Dihydrochalcone molecules destabilize Alzheimer's amyloid-β protofibrils through binding to the protofibril cavity
Alzheimer's disease (AD) is associated with the aggregation of amyloid-β (Aβ) peptides into
toxic fibrillar aggregates. Finding effective inhibitors of Aβ aggregation is a crucial step for …
toxic fibrillar aggregates. Finding effective inhibitors of Aβ aggregation is a crucial step for …
[HTML][HTML] Simulations on the dual effects of flavonoids as suppressors of Aβ42 fibrillogenesis and destabilizers of mature fibrils
SA Gargari, A Barzegar - Scientific Reports, 2020 - nature.com
Structural studies of the aggregation inhibition of the amyloid-β peptide (Aβ) by different
natural compounds are of the utmost importance due to their great potential as …
natural compounds are of the utmost importance due to their great potential as …