Autoimmune diseases are the result of specific immune responses directed against
structures of the self (Burnet and Fenner, 1949). The organism possesses powerful …

Autoimmune diseases are common diseases in which loss of tolerance within the immune
system results in pathologic immune responses that target either cellular or organ-specific …

No single theory or mechanism can adequately explain all features or pathogenesis of
autoimmune diseases. The clinically wide spectrum of autoimmune diseases is best …

The year of preparation of The Autoimmune Diseases 11 (1991) is the 40th anniversary of
the first cited adjectival description of “autoimmune,” in reference to hemolytic anemia …

The immune system specifically recognizes and eliminates foreign antigens and, thus,
protects integrity of the host. During maturation of the immune system, tolerance …

There are over 80 defined autoimmune diseases, characterized by the activation of the
immune system and tissue damage in the absence of an external threat to the organism …

In recent decades, an enormous effort has been made to elucidate the pathogenesis of
autoimmune and autoinflammatory diseases. Autoimmunity is a multifactorial process in …

Autoimmune disease occurs when a specific adaptive immune response is mounted against
self antigens. The normal consequence of an adaptive immune response against a foreign …

Monogenic autoimmune disorders provide a powerful tool for our understanding of the
principles of autoimmunity due to the obvious impact of a single gene on the disease. So far …

The past 12 months have witnessed several critical advancements and new particularly
promising lines of evidence on the pathogenesis and clinical management of autoimmune …