Autoimmune disease is characterized by clinical symptoms mediated by adaptive (T cell and
B cell) immune reactions towards autoantigen-expressing tissue. Here we discuss that …

In April 2007, an international Colloquium bridging scientific and clinical disciplines was
held to discuss the role of cellular and tissue damage in the initiation, development and …

For almost a century self-nonself discrimination has been considered the driving force of the
immune system and the dogma of self-tolerance (horror autotoxicus) the essential issue for …

Publisher Summary The term “autoimmune disease” signifies a condition in which the
immune system damages otherwise normal components of the individual. More recently …

Autoimmune disease: why and where it occurs | Nature Medicine Skip to main content Thank
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The immune system must be able to discriminate between self and non-self. However,
mechanisms of doing so sometimes fail, causing the activation and clonal expansion of …

The immune system specifically recognizes and eliminates foreign antigens and thus
protects the integrity of the host. During maturation of the immune system, tolerance …

Autoimmune diseases can be triggered and modulated by various molecular and cellular
characteristics. The mechanisms of autoimmunity and the pathogenesis of autoimmune …

It was not widely recognized, until the 1950s, that an immune response could be developed
not only against “foreign” but also “self” antigens from the studies of chronic thyroiditis …

“Research is to see what everybody else has seen, and to think what nobody else has
thought.”—Albert Szentgyörgyi Autoimmunity: Methods and Protocols is intended to serve as …