Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease,
relatively little is known about the precise nature of the immune dysregulation underlying the …

Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA
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Background Numerous cytokines are implicated in the immunopathogenesis of multiple
sclerosis (MS), but studies are often limited to whole blood (WB) or peripheral blood …

Cerebrospinal fluid (CSF) biomarkers are important for multiple sclerosis (MS) diagnosis.
Moreover, absent of autopsy or biopsy tissue, CSF is the most relevant source for studying …

Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central
nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis …

Introduction The understanding of the pathophysiology of multiple sclerosis (MS) has
evolved alongside the characterization of cytokines and chemokines in cerebrospinal fluid …

T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …

Multiple sclerosis (MS) is one of the most common neurological disorders in young adults.
The etiology of MS is not known, but it is generally accepted that it is autoimmune in nature …

The CNS has traditionally been considered an immune privileged site, but is now
understood to have a system of immune surveillance, predominantly involving CD4+ T-cells …

Peripheral central nervous system (CNS)–infiltrating lymphocytes are a hallmark of
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …