Conclusion The problems of improving drugs are so complex that a research worker will
never know if he has finally found the “best” compound in the series. In designing drugs …

The concept of structure-activity relationships (SAR) is a major paradigm in current
pharmacology, encompassing every type of biological activity (biological response) …

The great advances in biochemistry and molecular biology, the development of physical
organic chemistry, and the availability of large computers are creating opportunities for …

The rationalizationof connections between molecular structure and biological activity
comprises thefield of struc-ture-activity relationship (SAR) studies. Correlations between …

Antimicrobial and antiviral data sets were analyzed by molecular connectivity. Standard
structure‐activity relationship equations of high quality were produced in both cases. For …

In the broadest sense, all pharmacological stl1dies contribute to the body of knowledge
which empirically relates structure and pharmacological acн tion. The methodical …

The discussion of what are at present called" Structure-Action Relation ships" is fundamental
to the teaching of both pharmacology and medicinal chemistry. Such discussions assist also …

The readers of these Annual Reviews have been presented with several articles on relations
of chemical structure to biological activity in the last few years. Among them were the superb …

There have been a number of errors1 in the literature on quantitative structure-activity
relationships (QSAR) caused by a misunderstanding of points in the theory of linear …

Of the many approaches to theproblem of drug design, those of greatest current utility and
application are the regression techniques commonly associated with the names of Hansch1 …