Hyperhomocysteinemia: clinical insights

F Al Mutairi - Journal of central nervous system disease, 2020 - journals.sagepub.com
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite
formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can …

[HTML][HTML] The controversial role of homocysteine in neurology: from labs to clinical practice

R Moretti, P Caruso - International journal of molecular sciences, 2019 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin …

[HTML][HTML] Hyperhomocysteinemia and neurologic disorders: a review

R Ansari, A Mahta, E Mallack… - Journal of clinical …, 2014 - synapse.koreamed.org
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. It has a physiologic role in DNA metabolism via methylation, a process …

[PDF][PDF] Cardiovascular pathogenesis in hyperhomocysteinemia

T Huang, GF Yuan, ZG Zhang, ZQ Zou… - Asia Pacific journal of …, 2008 - apjcn.nhri.org.tw
Increased plasma homocysteine (Hcy) is a significant and independent risk factor for
cardiovascular disease. It can cause multi-disease manifestations such as smooth muscle …

[HTML][HTML] Homocysteine in neurology: a possible contributing factor to small vessel disease

R Moretti, M Giuffre, P Caruso, S Gazzin… - International Journal of …, 2021 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing amino acid generated during methionine
metabolism, accumulation of which may be caused by genetic defects or the deficit of …

[HTML][HTML] Involvements of hyperhomocysteinemia in neurological disorders

M Cordaro, R Siracusa, R Fusco, S Cuzzocrea… - Metabolites, 2021 - mdpi.com
Homocysteine (HCY), a physiological amino acid formed when proteins break down, leads
to a pathological condition called hyperhomocysteinemia (HHCY), when it is over a definite …

[HTML][HTML] The molecular and cellular effect of homocysteine metabolism imbalance on human health

H Škovierová, E Vidomanová, S Mahmood… - International journal of …, 2016 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in
methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is …

Hyperhomocysteinemia: impact on neurodegenerative diseases

M Sharma, M Tiwari, RK Tiwari - Basic & clinical pharmacology …, 2015 - Wiley Online Library
Neurodegenerative diseases are the diseases of the central nervous system with various
aetiology and symptoms. Dementia, Alzheimer's disease (AD), Parkinson's disease (PD) …

[HTML][HTML] Homocysteine: biochemistry, molecular biology and role in disease

A Hermann, G Sitdikova - Biomolecules, 2021 - mdpi.com
Homocysteine is a non-proteinogenic sulfhydryl-containing amino acid derived from
methionine and is a homologue of cysteine. The concentration of homocysteine is regulated …

Homocysteine and homocysteine-related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems

D Djuric, V Jakovljevic, V Zivkovic… - Canadian Journal of …, 2018 - cdnsciencepub.com
Homocysteine, an amino acid containing a sulfhydryl group, is an intermediate product
during metabolism of the amino acids methionine and cysteine. Hyperhomocysteinemia is …