Homocysteine and cerebral ischemia: pathogenic and therapeutical implications

A Pezzini, E Del Zotto… - Current medicinal …, 2007 - ingentaconnect.com
Homocysteine is a thiol aminoacid synthesized during the metabolism of methionine.
Increased plasma levels of homocysteine can be the result of mutations in the enzymes …

Hyperhomocysteinemia is an emerging comorbidity in ischemic stroke

R Poddar - Experimental neurology, 2021 - Elsevier
Hyperhomocysteinemia or systemic elevation of the amino acid homocysteine is a common
metabolic disorder that is considered to be a risk factor for ischemic stroke. However, it is still …

Hyperhomocysteinemia in adult patients: a treatable metabolic condition

D González-Lamuño, FJ Arrieta-Blanco, ED Fuentes… - Nutrients, 2023 - mdpi.com
Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for various
significant medical conditions, yet controversy persists around its assessment and …

[HTML][HTML] Hyperhomocysteinemia as a risk factor and potential nutraceutical target for certain pathologies

C Tinelli, A Di Pino, E Ficulle, S Marcelli… - Frontiers in …, 2019 - frontiersin.org
Hyperhomocysteinemia is recognized as a risk factor for several diseases, including
cardiovascular and neurological conditions. Homocysteine (HCys) is a key metabolite …

[HTML][HTML] Disturbed homocysteine metabolism is associated with cancer

T Hasan, R Arora, AK Bansal, R Bhattacharya… - … & molecular medicine, 2019 - nature.com
Hyperhomocysteinemia/Homocysteinuria is characterized by an increased level of toxic
homocysteine in the plasma. The plasma concentration of homocysteine is 5–15 μmol/L in …

Causes of hyperhomocysteinemia and its pathological significance

J Kim, H Kim, H Roh, Y Kwon - Archives of pharmacal research, 2018 - Springer
In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease
and a definite risk factor for many other diseases. Homocysteine is biosynthesized from …

Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets

Y Fu, X Wang, W Kong - British journal of pharmacology, 2018 - Wiley Online Library
Homocysteine is a sulphur‐containing non‐proteinogenic amino acid.
Hyperhomocysteinaemia (HHcy), the pathogenic elevation of plasma homocysteine as a …

Homocysteine and hyperhomocysteinaemia

BL Zaric, M Obradovic, V Bajic… - Current medicinal …, 2019 - ingentaconnect.com
Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all
humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is …

Homocysteine modification in protein structure/function and human disease

H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Homocysteine and disease: causal associations or epiphenomenons?

L Hannibal, HJ Blom - Molecular Aspects of Medicine, 2017 - Elsevier
Nutritional and genetic deficiencies of folate and vitamin B 12 lead to elevation of cellular
homocysteine (Hcy), which translates in increased plasma Hcy. The sources and role of …