Homocysteine: a biomarker in neurodegenerative diseases

W Herrmann, R Obeid - Clinical chemistry and laboratory medicine, 2011 - degruyter.com
Diseases of the central nervous system are found in patients with severe
hyperhomocysteinemia (HHcy). Epidemiological studies show a positive, dose-dependent …

The contribution of homocysteine metabolism disruption to endothelial dysfunction: state-of-the-art

R Esse, M Barroso, I Tavares de Almeida… - International journal of …, 2019 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the
metabolism of the essential amino acid methionine. Hcy is considered a risk factor for …

[HTML][HTML] Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID)

AH Hainsworth, NE Yeo, EM Weekman… - Biochimica et Biophysica …, 2016 - Elsevier
Homocysteine is produced physiologically in all cells, and is present in plasma of healthy
individuals (plasma [HCy]: 3–10 μM). While rare genetic mutations (CBS, MTHFR) cause …

The role of homocysteine levels as a risk factor of ischemic stroke events: A systematic review and meta-analysis

RT Pinzon, VO Wijaya, V Veronica - Frontiers in Neurology, 2023 - frontiersin.org
Introduction Among numerous risk factors, homocysteine (Hcy) has been linked to cerebral
infarction; however, results have been inconsistent. This review aimed to conduct a meta …

Homocysteine, intracellular signaling and thrombotic disorders

N Dionisio, I Jardín, GM Salido… - Current Medicinal …, 2010 - ingentaconnect.com
Homocysteine, a sulphur-containing amino acid derived from methionine, has been
presented as an independent risk factor for cardiovascular disorders, including …

Elevated homocysteine levels are associated with the metabolic syndrome and cardiovascular events in hypertensive patients

C Catena, G Colussi, F Nait… - American journal of …, 2015 - academic.oup.com
BACKGROUND Hyperhomocysteinemia and the metabolic syndrome are established
cardiovascular risk factors and are frequently associated with hypertension. The relationship …

Roles of homocysteine in cell metabolism: old and new functions

MÁ Medina, JL Urdiales… - European journal of …, 2001 - Wiley Online Library
Mild hyperhomocysteinemia has been suggested as a new, independent risk factor for
cardiovascular disease. This fact has produced a new, increased interest in the study of …

[HTML][HTML] Hyperhomocysteinemia

P Son, L Lewis - StatPearls [Internet], 2022 - ncbi.nlm.nih.gov
Objectives: Review the indications for obtaining a homocysteine level. Summarize who
should receive treatment for hyperhomocysteinemia. Identify patients who would have …

Hyperhomocysteinemia and oxidative stress: time for a reality check?

DW Jacobsen - Arteriosclerosis, thrombosis, and vascular biology, 2000 - Am Heart Assoc
Oxidative stress due to the production of intracellular and extracellular reactive oxygen
species may be a major player in the pathogenesis of cardiovascular and other diseases …

The metabolism and significance of homocysteine in nutrition and health

A Kumar, HA Palfrey, R Pathak, PJ Kadowitz… - Nutrition & …, 2017 - Springer
An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in
1969. Hcy is a sulfur containing amino acid derived from the essential amino acid …