Introduction Folic acid is the most important dietary determinant of homocysteine (Hcy). Hcy
serves as a critical intermediate in methylation reactions. It is created from methionine and …

Genetic disorders of homocysteine (Hcy) or folate metabolism or high-methionine diets
elevate plasma Hcy and its atherogenic metabolite Hcy-thiolactone. In humans, severe …

Homocysteine does not occur in the diet but it is an essential intermediate in normal
mammalian metabolism of methionine. Each compound, methionine or homocysteine, is the …

Arteriosclerosis and its complications, such as heart attack and stroke, are the major causes
of death in developed countries. It was believed that age, hyperlipidemia, hypertension …

Objective There is increasing interest in homocysteine as a risk factor for neuropsychiatric
disorders such as stroke, dementia, depression and Parkinson's disease. This article …

HC metabolism and vascular dysfunction. HC is formed upon demethylation of methionine
via S-adenosylmethionine (AdoMet) and S-adenosylhomocysteine (AdoHC). HC is …

Homocysteine (Hcy) is a non-protein forming amino acid which is the direct metabolic
precursor of methionine. Increased concentration of serum Hcy is considered a risk factor for …

Over the past few years, a substantial body of evidence has accumulated that indicates
hyperhomocysteinemia as a significant risk factor for cardiovascular disease …

Plasma homocysteine (HCY) is an established risk factor for cardiovascular disease CVD
and stroke. However, more than two decades of intensive research activities has failed to …

During the past year epidemiological studies have linked elevated plasma total
homocysteine concentrations with an increased risk of ischaemic stroke because of arterial …