Background Angiogenesis, the formation of new blood vessels from the endothelium of the
existing vasculature, is fundamental in tumor growth, progression, and metastasis. Inhibiting …

Angiogenesis plays an important role in the development of cancer since it allows for the
delivery of oxygen, nutrients, and growth factors as well as tumor dissemination to distant …

Angiogenesis is regulated by the balance of pro-angiogenic factors and angiogenesis
inhibitors, and the imbalance of these regulators is the cause of pathological angiogenesis …

Tumor angiogenesis is essential for the growth of primary and metastatic tumors. This
process requires the coordinated activities of multiple factors and cell types. For tumors to …

Angiogenesis is now recognized as a critical process in tumor progression and is required
for solid tumors to grow beyond a few millimeters in size. The transition from a non …

Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …

Angiogenesis is a key step in tumor growth, invasion and metastasis. Thus, antiangiogenic
therapy was postulated to be an attractive approach for antitumor treatment. Based on …

Angiogenesis is essential for progressive solid tumor growth and thus constitutes a very
promising therapeutic target. Recent developments in understanding of the molecular …

Tumor angiogenesis is a fast growing sub-domain of angiogenesis research and tumor
biology. Basic mechanisms have been unraveled and many key players identified. For many …

Mutations of oncogenes and tumor suppressor genes often lead to transformation of a
normal cell to become a malignant cell. However, most malignant cells cannot grow to a …