The identification and characterization of several important regulators of angiogenesis,
which led to Food and Drug Administration approval of the first antiangiogenic drugs, has …

Since 2004, four antiangiogenic drugs have been approved for clinical use in patients with
advanced solid cancers, on the basis of their capacity to improve survival in phase III clinical …

Malignant tumours are angiogenesis-dependent diseases. Several experimental studies
suggest that primary tumour growth, invasiveness and metastasis require …

[Frontiers in Bioscience 14, 3962-3973, January 1, 2009] 3962 Tumor angiogenesis and
molecular targets for therapy Yihai Cao Lab Page 1 [Frontiers in Bioscience 14, 3962-3973 …

Publisher Summary As normal cells progress to tumorigenicity, they must develop two
distinct new characteristics not possessed by the normal cells from which they arise: they …

Advances in molecular biology have permitted the characterisation of mechanisms
underlying angiogenesis. Angiogenesis is a crucial process in tumour pathogenesis as it …

The landmark papers published by Judah Folkman in the early 1970s on tumor
angiogenesis and therapeutic implications promoted the rapid development of a very …

Angiogenesis is essential for tumor growth and metastasis. Many signaling pathways are
involved in regulating tumor angiogenesis, with the vascular endothelial growth factor …

The development of a blood supply is crucial to the growth and metastasis of cancer. The
factors involved in this are complex, however tumour hypoxia and macrophage infiltration …

Besides antibodies against VEGF, that interfere with VEGF to block the angiogenic signaling
chain, several other strategies have been developed to interfere with VEGF signal …